The best way to get started quickly is to load any of the example projects in the Examples sub-folder of your TurbulenceFD installation and experiment with the settings. To create a scene from scratch, follow the following steps:
Select TurbulenceFD Container from the Plugins/TurbulenceFD Menu to create a fluid container for the simulation
Create one or several objects like spheres or such and move them inside of the container
Scale the objects down (or scale the container up) such that there's enough empty space in the container for the smoke/fire the spread
Attach the TurbulenceFD Emitter tag to all objects that will contribute to the simulation
Set the tag parameter Channels/Temperature Value to 1.0
Select Start Cached Simulation from the Plugins/TurbulenceFD menu.
A dialog with a progress bar appears as the simulation is being computed.
You can use Preview Fluid Container from the plugin menu to show a low quality preview of the current frame